Blood flow to the legs and feet is reduced when leg arteries are hardened and clogged. Peripheral arteries remain blocked, completely or partially, and cause pain, changes in skin color and temperature, sores or ulcers and difficulty walking. PAD, if left untreated, can lead to Critical Limb Ischemia (CLI), a condition where not enough blood is being delivered to the leg to keep the tissue alive. Gangrene ensues due to total loss of circulation to the legs and feet leading to amputation. Hardened arteries, in addition, found in people with PAD are a sign that they are likely to have hardened and narrowed arteries to the heart and the brain. That is why people with PAD are at high risk for having a heart attack or a stroke. They may become disabled and not be able to go to work, with the poor quality of life.